Publicaciones de Rafa Peláez

ÚLTIMAS PUBLICACIONES

Año	Título	*Referencia (Revista vol, pág.)*

	Microtubule Destabilizing Sulfonamides as An Alternative to Taxane-Based Chemotherapy	Int J Mol Sci 22, 1907
2021	Methylsulfanylpyridine based diheteroaryl isocombretastatin analogs as potent anti-proliferative agents	Eur J Med Chem 209, 112933

2020	Potent colchicine-site ligands with improved intrinsic solubility by replacement of the 3, 4, 5-trimethoxyphenyl ring with a 2-methylsulfanyl-6-methoxypyridine ring	Bioorg Chem 98, 103755

	Antitubulin sulfonamides: The successful combination of an established drug class and a multifaceted target.	Med Res Revs 39, 775
2019	The Bateman domain of IMP dehydrogenase is a binding target for dinucleoside polyphosphates.	J Biol Chem 294, 14768
	In Silico Molecular Studies of Antiophidic Properties of the Amazonian Tree Cordia nodosa Lam.	Molecules 24, E4160
	The Masked Polar Group Incorporation (MPGI) Strategy in Drug Design: Effects of Nitrogen Substitutions on Combretastatin and Isocombretastatin Tubulin Inhibitors	Molecules 24, E4319

2018	Substitution at the indole 3 position yields highly potent indolecombretastatins against human tumor cells	Eur J Med Chem 158, 167
	Bioactive Heterometallic CuII-ZnII Complexes with Potential Biomedical Applications	ACS OMEGA 3, 13343

2017	JADOPPT: java based AutoDock preparing and processing tool	Bioinformatics 33, 583

2016	N-(2-methyl-indol-1H-5-yl)-1-naphthalenesulfonamide: A novel reversible antimitotic agent inhibiting cancer cell motility	Biochem Pharm 115, 28-42
	Pyridine based antitumor compounds acting at the colchicine site	Curr Med Chem 23, 1100

2015	Exploring the size adaptability of the B ring binding zone of the colchicine site of tubulin with para-nitrogen substituted isocombretastatins	Eur J Med Chem 100, 210


2014	p,p-Dihydroxydihydrostilbenophanes Related to Antimitotic Combretastatins. Conformational Analysis and Its Relationship to Tubulin Inhibition	J Org Chem 79, 6840
	New Ligands of Tubulin Colchicine Site Based on X-Ray Structures	Curr Top Med Chem, 14, 2231

2013	Endowing Indole-Based Tubulin Inhibitors with an Anchor for Derivatization: Highly Potent 3-Substituted Indolephenstatins and Indoleisocombretastatins	J. Med. Chem. 56, 2813

	Bis-amidocarbazolyl urea receptor for short-chain dicarboxylate anions	Org Biomol Chem 10, 1181
2012	Total Synthesis of (+)-seco-C-Oleanane via Stepwise Controlled Radical Cascade Cyclization	J Org Chem 77, 341
	Lipid composition of Silybum marianum cell cultures treated with methyl jasmonate	Biol Plantar 56, 221

2011	New para–para Stilbenophanes: Synthesis by McMurry Coupling, Conformational Analysis and Inhibition of Tubulin Polymerisation	Chem Eur J 17, 3406

2010	Exploring the effect of 2,3,4-trimethoxy-phenyl moiety as a component of indolephenstatins	Eur J Med Chem 45, 588

2009	Design of New Chemoinformatic Tools for the Analysis of Virtual Screening Studies: Application to Tubulin Inhibitors	Adv Soft Comp 49, 189
	Isocombretastatins A: 1,1-Diarylethenes as potent inhibitors of tubulin polymerization and cytotoxic compounds	Bioorg. Med. Chem. 11, 8999

2008	Naphthylphenstatins as tubulin ligands: Synthesis and biological evaluation	Bioorg. Med. Chem. 11, 8999
	Diarylmethyloxime and hydrazone derivatives with 5-indolyl moieties as potent inhibitors of tubulin polymerization	Bioorg. Med. Chem. 11, 5952
	An arabinogalactan protein isolated from medium of cell suspension cultures of Silybum marianum (L.)Gaernt	Carboh. Polym. 71, 634
	Imino-Diels–Alder Reactions of 1-Aryl-3-(trialkylsiloxy)-1,3-butadienes in Solution and the Solid Phase	Eur. J. Org. Chem. 23, 4004

2007	New dicyclopentadiene-based scaffolds	Tetrahedron 63, 2132
	Synthesis and biological activity of naphthalene analogues of phenstatins: Naphthylphenstatins	Bioorg. Med. Chem. Lett. 17, 3417
	Synthesis and Conformational Analysis of Macrocyclic Dihydroxystilbenes linked up between para-para positions.	Chem. Eur. J. 13, 7246
	Conformationally restricted macrocyclic analogues of combretastatins	Bioorg. Med. Chem. Lett. 17, 6316
	Application of Chemoinformatic Tools for the Analysis of Virtual Screening Studies of Tubulin Inhibitors	Adv Soft Comp 44, 411

2006	Macrocyclic Chiral Receptors toward Enantioselective Recognition of Naproxen	Org. Lett. 8, 4679

2005	Stilbenophane Analogues of Deoxycombretastatin A-4	J. Org. Chem. 70, 6544	3,46
	Synthesis of a Conformationally Restricted Polyoxygenated Crownophane	Tetrahedron Lett. 46, 7055	2,48
	Further naphthylcombretastatins. An investigation on the role of the naphthalene moiety	J. Med. Chem. 48, 556	4,82
	New naphthylcombretastatins. Modifications on the ethylene bridge	Bioorg. Med. Chem. 13, 2097	2,19
	Intrisically Fluorescent Cytotoxic Cisplatin Analogues as DNA Marker Molecules	Bioconjugate Chem. 19, 275	3,55
	Diels-Alder reactivity of 4-aryl-1-phthalimido-2-siloxy-1,3-butadienes	Tetrahedron 61, 6871	2,64

2004	A new family of quinoline and quinoxaline analogues of combretastatins	Bioorg. Med. Chem. Lett. 14, 3771	2,33
	Naproxen: Hydroxypropyl-b-Cyclodextrin. Polyvinylpyrrolidone Ternary Complex Formation	J. Incl. Phenom. & Macroc. 48, 157	0,8
	1-Phthalimido-4-(3-indolyl)-2-siloxy-1,3-butadienes: synthesis and Diels-Alder reactivity	Tetrahedron Lett. 45, 1631	2,5

2003	Naphthalene Analogues of Lignans	J. Org. Chem. 68, 854	3,3