M. González, Y. Ellahioui, L. Gallego-Yerga, A. Vicente-Blázquez, R. Álvarez, M. Medarde and R. Peláez*. (2023) Novel amino analogs of the trimethoxyphenyl ring in potent colchicine site ligands improve solubility by the masked polar group incorporation (MPGI) strategy Bioorg. Chem. 131: 106282.
M. Ovejero-Sánchez, G. Asensio-Juárez, M. González, P. Puebla, M. Vicente-Manzanares, R. Pélaez, R. González-Sarmiento, A. Belén Herrero*. (2022) Panobinostat Synergistically Enhances the Cytotoxicity of Microtubule Destabilizing Drugs in Ovarian Cancer Cells Int. J. Mol. Sci. 21, 13019.
R. Álvarez, L. Aramburu, C. Gajate, A. Vicente-Blázquez, F. Mollinedo, M. Medarde and R. Pelaéz*. Methylsulfanylpyridine based diheteroaryl isocombretastatin analogs as potent anti-proliferative agents. (2021) Eur J Med Chem 209: 112933.
S. Pecnard, A. Hamze, J. Bignon, B. Prost, A. Deroussent, L. Gallego-Yerga, R. Peláez, J. Y. Paik, M. Diederich, M. Alami, O. Provot. Anticancer properties of indole derivatives as IsoCombretastatin A-4 analogues. (2021) Eur J Med Chem 223: 1768-3254.
M. González, M. Ovejero-Sánchez, A. Vicente-Blázquez, M. Medarde, R. González-Sarmiento and R Peláez*. Methoxy and bromo scans on N-(5-methoxyphenyl) methoxybenzene sulphonamides reveal potent cytotoxic compounds, especially against the human breast adenocarcinoma MCF7 cell line. (2021) J Enz Inh Med Chem 36: 1029-1047.
M. González, M. Ovejero-Sánchez, A. Vicente-Blázquez, R. Álvarez, A. B. Herrero, M. Medarde, R. González-Sarmiento* and R. Peláez*. Microtubule Destabilizing Sulfonamides as an Alternative to Taxane-Based Chemotherapy. (2021) Int J Mol Sci 22(4): 1907.
A. Vicente-Blázquez, M. González, M. Medarde, F. Mollinedo* and R. Peláez*. New indolesulfonamide derivatives targeting the colchicine site of tubulin: synthesis, anti-tumour activity, structure–activity relationships, and molecular modelling. (2021) J Enz Inh Med Chem 36:1, 2025-2044.
R. Álvarez, L. Aramburu, C. Gajate, A. Vicente-Blázquez, F. Mollinedo, M. Medarde and R. Pelaéz*. (2020) Pyridine A ring analogues of combretastatins and isocombretastatins as potent cytotoxic agents Bioorg Chem , 98, 103755. .
Marín-Ramos, N. I., ….F. Mollinedo, et al (2019). "A Potent Isoprenylcysteine Carboxylmethyltransferase (ICMT) Inhibitor Improves Survival in Ras-Driven Acute Myeloid Leukemia." J Med Chem 62(13): 6035-6046.
R. Álvarez, C. Gajate, P. Puebla, F. Mollinedo, M. Medarde and R. Peláez (2018). "Substitution at the indole 3 position yields highly potent indolecombretastatins against human tumor cells." Eur J Med Chem 158: 167-183.
Bello, C…, F. Mollinedo and P. Vogel (2018). "Induction of cell killing and autophagy by amphiphilic pyrrolidine derivatives on human pancreatic cancer cells." Eur J Med Chem 150: 457-478.
Majumder, I., P. Chakraborty, R. Alvarez, M. Gonzalez-Diaz, R. Pelaez, et al (2018). "Bioactive Heterometallic Cu(II)-Zn(II) Complexes with Potential Biomedical Applications." ACS Omega 3(10): 13343-13353.
Marín-Ramos, N. I., ….F. Mollinedo, et al (2017). "Development of a Nucleotide Exchange Inhibitor That Impairs Ras Oncogenic Signaling." Chemistry 23: 1676-1685.
Jimenez, C., Y. Ellahioui, R. Alvarez, …. and R. Pelaez (2015). "Exploring the size adaptability of the B ring binding zone of the colchicine site of tubulin with para-nitrogen substituted isocombretastatins." Eur J Med Chem 100: 210-222.
Aceves-Luquero, C., .... R. Pelaez, et al (2016). "N-(2-methyl-indol-1H-5-yl)-1-naphthalenesulfonamide: A novel reversible antimitotic agent inhibiting cancer cell motility." Biochem Pharmacol 115: 28-42.
Alvarez, R., P. Puebla, ... F. Mollinedo, J. M. Andreu, M. Medarde and R. Pelaez (2013). "Endowing indole-based tubulin inhibitors with an anchor for derivatization: highly potent 3-substituted indolephenstatins and indoleisocombretastatins." J Med Chem 56(7): 2813-2827.

M. González, P. Alcolea, R. Álvarez, M. Medarde, V. Larraga and Pelaéz, R. "New antimitotic diarylsulfonamide inhibitors of Leishmania infantum amastigotes." Int J Paras Drug Drug Res 2021, 16, 45-64.
J. A. Villa-Pulgarín….. and F. Mollinedo (2017). "Mitochondria and lipid raft-located FOF1-ATP synthase as major therapeutic targets in the antileishmanial and anticancer activities of ether lipid edelfosine." PLoS Negl Trop Dis 11(8): e0005805.
M. R. Varela, R. Ochoa, C. E. Muskus, A. Muro and F. Mollinedo (2017). "Identification of a RAC/AKT-like gene in Leishmania parasites as a putative therapeutic target in leishmaniasis." Parasit Vectors 10(1): 458.
Navrátilová, A., …. F. Mollinedo, et al (2016). "C-Geranylated flavonoids from Paulownia tomentosa fruits with antimicrobial potential and synergistic activity with antibiotics." Pharm Biol 54(8): 1398-1407.
Varela, M. R., ..... and F. Mollinedo (2014). "The HSP90 inhibitor 17-AAG potentiates the antileishmanial activity of the ether lipid edelfosine." Acta Trop 131: 32-36.
Varela, M. R., …. and F. Mollinedo (2012). "In vitro and in vivo efficacy of ether lipid edelfosine against Leishmania spp. and SbV-resistant parasites." PLoS Negl Trop Dis 6(4): e1612.
F. Mollinedo, et al (2010). "Selective fusion of azurophilic granules with Leishmania-containing phagosomes in human neutrophils." J Biol Chem 285(45): 34528-34536.
Alzate, J. F., A. Arias, F. Mollinedo, et al (2008). "Edelfosine induces an apoptotic process in Leishmania infantum that is regulated by the ectopic expression of Bcl-XL and Hrk." Antimicrob Agents Chemother 52(10): 3779-3782.

M. Ovejero-Sánchez, G. Asensio-Juárez, M. González, P. Puebla, M. Vicente-Manzanares, R. Pélaez, R. González-Sarmiento, A. Belén Herrero*. (2022) Panobinostat Synergistically Enhances the Cytotoxicity of Microtubule Destabilizing Drugs in Ovarian Cancer Cells Int. J. Mol. Sci. 21, 13019.
L. Gallego-Yerga, R. Ochoa, I. Lans, C. Peña-Varas, M. Alegría-Arcos, P. Cossio, D. Ramírez*, R. Peláez*. Application of ensemble pharmacophore-based virtual screening to the discovery of novel antimitotic tubulin inhibitors. (2021) Comp. Str. Biotech. J. 19: 4360-4372.
Álvarez, R., L. Aramburu, C. Gajate, A. Vicente-Blázquez, F. Mollinedo, M. Medarde and R. Peláez (2020). "Potent colchicine-site ligands with improved intrinsic solubility by replacement of the 3,4,5-trimethoxyphenyl ring with a 2-methylsulfanyl-6-methoxypyridine ring." Bioorg Chem 98: 103755.
Vicente-Blazquez, A., M. Gonzalez, R. Alvarez, S. Del Mazo, M. Medarde and R. Pelaez (2019). "Antitubulin sulfonamides: The successful combination of an established drug class and a multifaceted target." Med Res Rev 39(3): 775-830
Álvarez, R., C. Gajate, P. Puebla, F. Mollinedo, M. Medarde and R. Peláez (2018). "Substitution at the indole 3 position yields highly potent indolecombretastatins against human tumor cells." Eur J Med Chem 158: 167-183.
Aceves-Luquero, C., … R. Pelaez, et al (2016). "N-(2-methyl-indol-1H-5-yl)-1-naphthalenesulfonamide: A novel reversible antimitotic agent inhibiting cancer cell motility." Biochem Pharmacol 115: 28-42.
Alvarez, R., L. Aramburu, P. Puebla, E. Caballero, M. Gonzalez, A. Vicente, M. Medarde and R. Pelaez (2016). "Pyridine Based Antitumour Compounds Acting at the Colchicine Site." Curr Med Chem 23(11): 1100-1130.
Jimenez, C., Y. Ellahioui, R. Alvarez, … M. Medarde, E. Caballero and R. Pelaez (2015). "Exploring the size adaptability of the B ring binding zone of the colchicine site of tubulin with para-nitrogen substituted isocombretastatins." Eur J Med Chem 100: 210-222.
Alvarez, R., V. Lopez, C. Mateo, M. Medarde and R. Pelaez (2014). "p,p-Dihydroxydihydrostilbenophanes related to antimitotic combretastatins. Conformational analysis and its relationship to tubulin inhibition." J Org Chem 79(15): 6840-6857.
Alvarez, R., M. Medarde and R. Pelaez (2014). "New ligands of the tubulin colchicine site based on X-ray structures." Curr Top Med Chem 14(20): 2231-2252.
Alvarez, R., P. Puebla, J. F. Diaz, A. C. Bento, R. Garcia-Navas, J. de la Iglesia-Vicente, F. Mollinedo, J. M. Andreu, M. Medarde and R. Pelaez (2013). "Endowing indole-based tubulin inhibitors with an anchor for derivatization: highly potent 3-substituted indolephenstatins and indoleisocombretastatins." J Med Chem 56(7): 2813-2827.
Alvarez, R., V. Lopez, C. Mateo, M. Medarde and R. Pelaez (2011). "New para-para stilbenophanes: synthesis by McMurry coupling, conformational analysis and inhibition of tubulin polymerisation." Chemistry 17(12): 3406-3419

M. Ovejero-Sánchez, G. Asensio-Juárez, M. González, P. Puebla, M. Vicente-Manzanares, R. Pélaez, R. González-Sarmiento, A. Belén Herrero*. (2022) Panobinostat Synergistically Enhances the Cytotoxicity of Microtubule Destabilizing Drugs in Ovarian Cancer Cells Int. J. Mol. Sci. 21, 13019.
Klionsky, D. J., … F. Mollinedo, et al (2021). "Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)." Autophagy 17(1): 1-382.
Mollinedo, F. et al. (2020). "Lipid rafts as signaling hubs in cancer cell survival/death and invasion: implications in tumor progression and therapy." J Lipid Res 61(5): 611-635.
Fernandez-Justel, D., R. Pelaez, J. L. Revuelta and R. M. Buey (2019). "The Bateman domain of IMP dehydrogenase is a binding target for dinucleoside polyphosphates." J Biol Chem 294(40): 14768-14775.
Dakir, E. H. and F. Mollinedo (2019). "Genome-wide miRNA profiling and pivotal roles of miRs 125a-5p and 17-92 cluster in human neutrophil maturation and differentiation of acute myeloid leukemia cells." Oncotarget 10(51): 5313-5331.
Mollinedo, F. and C. Gajate (2019). "Novel therapeutic approaches for pancreatic cancer by combined targeting of RAF→MEK→ERK signaling and autophagy survival response." Ann Transl Med 7(Suppl 3): S153.
Villa-Pulgarín, J. A., C. Gajate, … and F. Mollinedo (2017). "Mitochondria and lipid raft-located FOF1-ATP synthase as major therapeutic targets in the antileishmanial and anticancer activities of ether lipid edelfosine." PLoS Negl Trop Dis 11(8): e0005805.
Varela, M. R., R. Ochoa, C. E. Muskus, A. Muro and F. Mollinedo (2017). "Identification of a RAC/AKT-like gene in Leishmania parasites as a putative therapeutic target in leishmaniasis." Parasit Vectors 10(1): 458.
Aceves-Luquero, C., … R. Pelaez, J. M. Llinares, M. E. Gonzalez-Rosende and P. Villalonga (2016). "N-(2-methyl-indol-1H-5-yl)-1-naphthalenesulfonamide: A novel reversible antimitotic agent inhibiting cancer cell motility." Biochem Pharmacol 115: 28-42.
Legarda-Ceballos, A. L., … C. Gajate, F. Mollinedo and A. Muro (2016). "The alkylphospholipid edelfosine shows activity against Strongyloides venezuelensis and induces apoptosis-like cell death." Acta Trop 162: 180-187.
Yepes, E., … A. Muro and F. Mollinedo (2015). "Inhibition of Granulomatous Inflammation and Prophylactic Treatment of Schistosomiasis with a Combination of Edelfosine and Praziquantel." PLoS Negl Trop Dis 9(7): e0003893
Bonilla, X., H. Dakir el, F. Mollinedo and C. Gajate (2015). "Endoplasmic reticulum targeting in Ewing's sarcoma by the alkylphospholipid analog edelfosine." Oncotarget 6(16): 14596-14613.
Melo-Lima, S., C. Gajate and F. Mollinedo (2015). "Triggers and signaling cross-talk controlling cell death commitment." Cell Cycle 14(4): 465-466.
Sánchez-Blanco, A., A. G. Rodríguez-Matellán, M. Reis-Sobreiro, B. Sáenz-Narciso, J. Cabello, W. A. Mohler and F. Mollinedo (2014). "Caenorhabditis elegans as a platform to study the mechanism of action of synthetic antitumor lipids." Cell Cycle 13(21): 3375-3389.

M. González, Y. Ellahioui, L. Gallego-Yerga, A. Vicente-Blázquez, R. Álvarez, M. Medarde and R. Peláez*. (2023) Novel amino analogs of the trimethoxyphenyl ring in potent colchicine site ligands improve solubility by the masked polar group incorporation (MPGI) strategy Bioorg. Chem. 131: 106282.
R. Álvarez, L. Aramburu, C. Gajate, A. Vicente-Blázquez, F. Mollinedo, M. Medarde and R. Pelaéz*. Methylsulfanylpyridine based diheteroaryl isocombretastatin analogs as potent anti-proliferative agents. (2021) Eur J Med Chem 209: 112933.
S. Pecnard, A. Hamze, J. Bignon, B. Prost, A. Deroussent, L. Gallego-Yerga, R. Peláez, J. Y. Paik, M. Diederich, M. Alami, O. Provot. Anticancer properties of indole derivatives as IsoCombretastatin A-4 analogues. (2021) Eur J Med Chem 223: 1768-3254.
M. González, M. Ovejero-Sánchez, A. Vicente-Blázquez, M. Medarde, R. González-Sarmiento and R Peláez*. Methoxy and bromo scans on N-(5-methoxyphenyl) methoxybenzene sulphonamides reveal potent cytotoxic compounds, especially against the human breast adenocarcinoma MCF7 cell line. (2021) J Enz Inh Med Chem 36: 1029-1047.
M. González, M. Ovejero-Sánchez, A. Vicente-Blázquez, R. Álvarez, A. B. Herrero, M. Medarde, R. González-Sarmiento* and R. Peláez*. Microtubule Destabilizing Sulfonamides as an Alternative to Taxane-Based Chemotherapy. (2021) Int J Mol Sci 22(4): 1907.
A. Vicente-Blázquez, M. González, M. Medarde, F. Mollinedo* and R. Peláez*. New indolesulfonamide derivatives targeting the colchicine site of tubulin: synthesis, anti-tumour activity, structure–activity relationships, and molecular modelling. (2021) J Enz Inh Med Chem 36:1, 2025-2044.
Álvarez, R., L. Aramburu, C. Gajate, A. Vicente-Blázquez, F. Mollinedo, M. Medarde and R. Peláez (2020). "Potent colchicine-site ligands with improved intrinsic solubility by replacement of the 3,4,5-trimethoxyphenyl ring with a 2-methylsulfanyl-6-methoxypyridine ring." Bioorg Chem 98: 103755.
Vicente-Blazquez, A., M. Gonzalez, R. Alvarez, S. Del Mazo, M. Medarde and R. Pelaez (2019). "Antitubulin sulfonamides: The successful combination of an established drug class and a multifaceted target." Med Res Rev 39(3): 775-830
Álvarez, R., C. Gajate, P. Puebla, F. Mollinedo, M. Medarde and R. Peláez (2018). "Substitution at the indole 3 position yields highly potent indolecombretastatins against human tumor cells." Eur J Med Chem 158: 167-183.
Majumder, I., P. Chakraborty, R. Alvarez, M. Gonzalez-Diaz, R. Pelaez, et al (2018). "Bioactive Heterometallic Cu(II)-Zn(II) Complexes with Potential Biomedical Applications." ACS Omega 3(10): 13343-13353.
Jimenez, C., Y. Ellahioui, R. Alvarez, … M. Medarde, E. Caballero and R. Pelaez (2015). "Exploring the size adaptability of the B ring binding zone of the colchicine site of tubulin with para-nitrogen substituted isocombretastatins." Eur J Med Chem 100: 210-222.
Alvarez, R., V. Lopez, C. Mateo, M. Medarde and R. Pelaez (2014). "p,p-Dihydroxydihydrostilbenophanes related to antimitotic combretastatins. Conformational analysis and its relationship to tubulin inhibition." J Org Chem 79(15): 6840-6857.
Alvarez, R., P. Puebla… F. Mollinedo, J. M. Andreu, M. Medarde and R. Pelaez (2013). "Endowing indole-based tubulin inhibitors with an anchor for derivatization: highly potent 3-substituted indolephenstatins and indoleisocombretastatins." J Med Chem 56(7): 2813-2827.
Alvarez, R., V. Lopez, C. Mateo, M. Medarde and R. Pelaez (2011). "New para-para stilbenophanes: synthesis by McMurry coupling, conformational analysis and inhibition of tubulin polymerisation." Chemistry 17(12): 3406-3419.

L. Gallego-Yerga, R. Ochoa, I. Lans, C. Peña-Varas, M. Alegría-Arcos, P. Cossio, D. Ramírez*, R. Peláez*. Application of ensemble pharmacophore-based virtual screening to the discovery of novel antimitotic tubulin inhibitors. (2021) Comp. Str. Biotech. J. 19: 4360-4372.
A. Vicente-Blázquez, M. González, M. Medarde, F. Mollinedo* and R. Peláez*. New indolesulfonamide derivatives targeting the colchicine site of tubulin: synthesis, anti-tumour activity, structure–activity relationships, and molecular modelling. (2021) J Enz Inh Med Chem 36:1044.
Gonzalez, M., Y. Ellahioui, R. Alvarez, L. Gallego-Yerga, E. Caballero, … M. Medarde and R. Pelaez (2019). "The Masked Polar Group Incorporation (MPGI) Strategy in Drug Design: Effects of Nitrogen Substitutions on Combretastatin and Isocombretastatin Tubulin Inhibitors." Molecules 24(23).
Fernandez-Justel, D., R. Pelaez, et al (2019). "The Bateman domain of IMP dehydrogenase is a binding target for dinucleoside polyphosphates." J Biol Chem 294(40): 14768-14775.
Luzuriaga-Quichimbo, C. X., … R. Pelaez, et al (2019). "In Silico Molecular Studies of Antiophidic Properties of the Amazonian Tree Cordia nodosa Lam." Molecules 24(22).
Álvarez, R., C. Gajate, P. Puebla, F. Mollinedo, M. Medarde and R. Peláez (2018). "Substitution at the indole 3 position yields highly potent indolecombretastatins against human tumor cells." Eur J Med Chem 158: 167-183.
Garcia-Perez, C., R. Pelaez, et al (2017). "JADOPPT: java based AutoDock preparing and processing tool." Bioinformatics 33(4): 583-585.
Varela-Salinas, G., C. A. García-Pérez, R. Peláez et al (2017). Visual Clustering Approach for Docking Results from Vina and AutoDock, Cham, Springer International Publishing.
Jimenez, C., Y. Ellahioui, R. Alvarez, … M. Medarde, E. Caballero and R. Pelaez (2015). "Exploring the size adaptability of the B ring binding zone of the colchicine site of tubulin with para-nitrogen substituted isocombretastatins." Eur J Med Chem 100: 210-222.
Alvarez, R., M. Medarde and R. Pelaez (2014). "New ligands of the tubulin colchicine site based on X-ray structures." Curr Top Med Chem 14(20): 2231-2252.
Alvarez, R., P. Puebla, … F. Mollinedo, J. M. Andreu, M. Medarde and R. Pelaez (2013). "Endowing indole-based tubulin inhibitors with an anchor for derivatization: highly potent 3-substituted indolephenstatins and indoleisocombretastatins." J Med Chem 56(7): 2813-2827.
Alvarez, R., V. Lopez, C. Mateo, M. Medarde and R. Pelaez (2011). "New para-para stilbenophanes: synthesis by McMurry coupling, conformational analysis and inhibition of tubulin polymerisation." Chemistry 17(12): 3406-3419.

M. González, Y. Ellahioui, L. Gallego-Yerga, A. Vicente-Blázquez, R. Álvarez, M. Medarde and R. Peláez*. (2023) Novel amino analogs of the trimethoxyphenyl ring in potent colchicine site ligands improve solubility by the masked polar group incorporation (MPGI) strategy Bioorg. Chem. 131: 106282.
L. Gallego-Yerga, Cristina de la Torre, Francesco Sansone, Alessandro Casnati, Carmen Ortiz Mellet, José M.García Fernández, Valentín Ceña. Synthesis, self-assembly and anticancer drug encapsulation and delivery properties of cyclodextrin-based giant amphiphiles. (2021) Carbohydr Polym252, 117135.
L. Gallego-Yerga, Valentín Ceña. (2020) Nanoparticle-mediated therapeutic compounds delivery to glioblastoma. Expert Opin Drug Delivery17: 1541-1554.
Álvarez, R., L. Aramburu, C. Gajate, A. Vicente-Blázquez, F. Mollinedo, M. Medarde and R. Peláez (2021). "Potent colchicine-site ligands with improved intrinsic solubility by replacement of the 3,4,5-trimethoxyphenyl ring with a 2-methylsulfanyl-6-methoxypyridine ring." Bioorg Chem 98: 103755.
Gonzalez, M., Y. Ellahioui, R. Alvarez, L. Gallego-Yerga, E. Caballero, ... M. Medarde and R. Pelaez (2019). "The Masked Polar Group Incorporation (MPGI) Strategy in Drug Design: Effects of Nitrogen Substitutions on Combretastatin and Isocombretastatin Tubulin Inhibitors." Molecules 24(23).
González-Fernández, Y., … F. Mollinedo, et al (2017) "Doxorubicin and edelfosine lipid nanoparticles are effective acting synergistically against drug-resistant osteosarcoma cancer cells." Cancer Lett 388: 262-268.
Alvarez, R., V. Lopez, C. Mateo, M. Medarde and R. Pelaez (2014). "p,p-Dihydroxydihydrostilbenophanes related to antimitotic combretastatins. Conformational analysis and its relationship to tubulin inhibition." J Org Chem 79(15): 6840-6857.
Alvarez, R., P. Puebla, ... F. Mollinedo, J. M. Andreu, M. Medarde and R. Pelaez (2013). "Endowing indole-based tubulin inhibitors with an anchor for derivatization: highly potent 3-substituted indolephenstatins and indoleisocombretastatins." J Med Chem 56(7): 2813-2827.
Burgeiro, A., … F. Mollinedo and P. J. Oliveira (2013). "Edelfosine and perifosine disrupt hepatic mitochondrial oxidative phosphorylation and induce the permeability transition." Mitochondrion 13(1): 25-35.
Cuesta-Marbán, Á., … C. Gajate, … and F. Mollinedo (2013). "Drug uptake, lipid rafts, and vesicle trafficking modulate resistance to an anticancer lysophosphatidylcholine analogue in yeast." J Biol Chem 288(12): 8405-8418.
Alvarez, R., C. Alvarez, F. Mollinedo, B. G. Sierra, M. Medarde and R. Peláez (2009). "Isocombretastatins A: 1,1-diarylethenes as potent inhibitors of tubulin polymerization and cytotoxic compounds." Bioorg Med Chem 17(17): 6422-6431.